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SARS-COV-2 Spike S1 Protein Antibody [7D10U4]

Product Specifications

Background

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It''s been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

NCBI Gene ID

43740568

Swiss Prot

P0DTC2

Accession Number

YP_009724390.1

Host

Rabbit

Reactivity

Virus

Immunogen

HEK293 derived SARS-COV-2 SPIKE S1, amino acids Val16-Arg685

Clonality

Recombinant Monoclonal

Clone

7D10U4

Conjugation

Unconjugated

Type

Primary Antibodies, Antibody Pairs

Field of Research

Infectious Disease, COVID-19

Purification

Affinity Purified, Endotoxin Level: < 1.0 EU/ug of the protein by LAL method.

Concentration

1mg/ml

Buffer

Supplied as a 0.2um filtered solution in PBS, pH 7.4.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

This antibody can be stored at 2&#730; C to -8&#730; C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20&#730; C to -80&#730; C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Specificity

SARS-CoV-2

Applications Notes

ELISA Capture: Recommended Concentration: 1-4ug/mL, Sample: SARS-COV-2 Spike S1 Protein Antibody (CAP) ELISA Detection: Recommended Concentration: 0.05-0.2ug/mL, Sample: SARS-COV-2 Spike S1 Protein Antibody (DET) Standard: Recommended Concentration: 156-10000pg/mL, Sample: Recombinant SARS-COV-2 Spike S1 Protein with His tag

Symbol

S

NCBI Official Name

Surface glycoprotein

NCBI Organism

Severe acute respiratory syndrome coronavirus 2

Other Product Names

Spike glycoprotein

Tested Applications

ELISA

Protein ID

1796318598

Physical Properties

Liquid

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