IL-6 Antibody [2M8M3]

Product Specifications

Background

Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable) . The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable) .

NCBI Gene ID

3569

Swiss Prot

P05231

Host

Rabbit

Reactivity

Virus

Immunogen

E. coli-derived human IL-6 protein, amino acids Pro29-Met212

Clonality

Recombinant Monoclonal

Clone

2M8M3

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease, COVID-19

Purification

Affinity Purified, Endotoxin Level: < 1.0 EU/ug of the protein by LAL method.

Concentration

1mg/ml

Buffer

Supplied as a 0.2um filtered solution in PBS, pH 7.4.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

This antibody can be stored at 2˚ C to -8˚ C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20˚ C to -80˚ C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Applications Notes

ELISA Capture: Recommended Concentration: 1-4ug/mL, Sample: Human IL-6 Monoclonal Antibody, Rabbit MAb (CAP) ELISA Detection: Recommended Concentration: 0.03-0.15ug/mL, Sample: Human IL-6 Monoclonal Antibody, Rabbit MAb (DET) Standard: Recommended Concentration: 0.78-50pg/mL, Sample: Recombinant Human IL6 Protein