IL-2 Antibody [1Q8G7]

Interleukin-2 (IL-2) is a O-glycosylated, four alpha -helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL-2 and IL-2 R alpha synthesis. IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells.

This antibody can be stored at 2˚ C to -8˚ C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20˚ C to -80˚ C. Preservative-Free. Avoid repeated freeze-thaw cycles.

ELISA Capture: Recommended Concentration: 2-8ug/mL, Sample: Human IL-2 Monoclonal Antibody, Rabbit MAb (CAP) ELISA Detection: Recommended Concentration: 0.15-0.5ug/mL, Sample: Human IL-2 Monoclonal Antibody, Rabbit MAb (DET) Standard: Recommended Concentration: 0.78-50pg/mL, Sample: Recombinant Human IL2 Protein