PRMT1 Antibody

Product Specifications

Background

Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology.

NCBI Gene ID

3276

Swiss Prot

Q99873

Accession Number

Q99873

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PRMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the C-terminal region of human PRMT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

42 kDa

Fragment

Rabbit Ig

Symbol

PRMT1

NCBI Official Name

Protein arginine N-methyltransferase 1

NCBI Organism

Homo sapiens

Background Reference 01

Zhang, X., et al., EMBO J. 19 (14) :3509-3519 (2000) .

Background Reference 02

Scorilas, A., et al., Biochem. Biophys. Res. Commun. 278 (2) :349-359 (2000) .

Background Reference 03

Scott, H.S., et al., Genomics 48 (3) :330-340 (1998) .

Background Reference 04

Abramovich, C., et al., EMBO J. 16 (2) :260-266 (1997) .

Other Product Names

Protein arginine N-methyltransferase 1, 211-, Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4, PRMT1, HMT2, HRMT1L2, IR1B4