PRMT1 Antibody
Product Specifications
Background
Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all 7 PRMT members have been developed.
NCBI Gene ID
3276
Swiss Prot
Q99873
Accession Number
Q99873
Host
Rabbit
Reactivity
Human
Immunogen
This PRMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-347 amino acids from the C-terminal region of human PRMT1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Symbol
PRMT1
NCBI Official Name
Protein arginine N-methyltransferase 1
NCBI Organism
Homo sapiens
Background Reference 01
Zhang, X., et al., EMBO J. 19 (14) :3509-3519 (2000) .
Background Reference 02
Scorilas, A., et al., Biochem. Biophys. Res. Commun. 278 (2) :349-359 (2000) .
Background Reference 03
Scott, H.S., et al., Genomics 48 (3) :330-340 (1998) .
Background Reference 04
Abramovich, C., et al., EMBO J. 16 (2) :260-266 (1997) .
Other Product Names
Protein arginine N-methyltransferase 1, 211-, Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4, PRMT1, HMT2, HRMT1L2, IR1B4
Tested Applications
WB, IHC-P
Protein ID
161789011
Physical Properties
Liquid
Frequently Asked Questions
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