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MNDA (CT) Antibody

Product Specifications

Background

MNDA Antibody: MNDA controls the expression of MCL-1 and BCL02 in chronic lymphocytic leukemia cells. MNDA is also a useful marker in the recognition and differential diagnosis of marginal zone lymphomas. MNDA has a role in regulating programmed cell death in myeloid progenitor cells, and its down-regulation in myelodysplastic syndromes is related to granulocyte-macrophage progenitor cell sensitivity to TRAIL-induced programmed cell death.

NCBI Gene ID

4332

Swiss Prot

P41218.1

Accession Number

P41218.1

Host

Rabbit

Reactivity

Human

Immunogen

9645

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

MNDA Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1208 - THP-1 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Gorilla (100%), chimpanzee (100%), Monkey (92%)

Buffer

MNDA Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

MNDA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=9645

Fragment

IgG

Applications Notes

WB: 1 μ g/mL; IHC: 2 μ g/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples. All other applications and species not yet tested.

Isoform

Human MNDA has one isoform (407aa, 45.8kD) . Mouse MNDA has 2 isoforms, isoform 1 (425aa, 47kD) and isoform 2 (423aa, 46.8kD) . Rat MNDA has one isoform (438aa, 49.7kD) . 9645 can detect MNDA in human, but not in mouse and rat.

Symbol

MNDA

Positive Control 2

Cat. No. 17-008 – THP-1 Cell Slide

NCBI Official Name

Myeloid cell nuclear differentiation antigen

NCBI Organism

Homo sapiens

Background Reference 01

Bottari et al. Exp Hematol. 2020; 88:68-82

Background Reference 02

Wang et al. Am. J. Clin. Pathol. 2019; 151 (3) :337-343

Background Reference 03

Kanellis et al. Lukemia 2019; 23 (10) :1847-1857

Background Reference 04

Briggs et al. Cancer Res. 2006; 66 (9) : 4645-4651

Other Product Names

MNDA

Tested Applications

ELISA, WB, IHC

Protein ID

730038

Physical Properties

Liquid

Available Sizes

Curated Selection

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