IFI16 (CT) Antibody

Product Specifications

Background

IFI16 Antibody: IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer. Increased expression of IFI16 predicts adverse prognosis in multiple myeloma. IFI16 isoforms with cytoplasmic and nuclear locations play differential roles in recognizing invaded DNA viruses. IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection. Nuclear sensor IFI16 inhibits the function of Hepatitis B virus covalently closed circular DNA by integrating innate immune activation and epigenetic suppression.

NCBI Gene ID

3428

Swiss Prot

Q16666

Accession Number

Q16666.3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

9641

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Cell Cycle, Transcription

Purification

IFI16 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1204 - K562 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Gorilla (100%), chimpanzee (100%)

Buffer

IFI16 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IFI16 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human IFI16 has 4 isoforms, including isoform 1 (785aa, 8.3kD), isoform 2 (729aa, 82.1kD), isoform 3 (673aa, 75.9kD), and isoform 4 (729aa, 82.6kD)

Symbol

IFI16

Positive Control 2

Cat. No. 17-06 - Molt4 Cell Slide

NCBI Official Name

Interferon gamma inducible protein 16

NCBI Organism

Homo sapiens

Background Reference 01

Ka et al. Cell Rep. 2021; 37 (12) :110138

Background Reference 02

Huang et al. Pharmacogenomics J. 2021; 21 (4) :520-532

Background Reference 03

Li et al. J Immunol. 2021; 207 (11) :2699-2709

Background Reference 04

Jiang et al. Nat Microbiol. 2021; 6 (7) :932-945

Background Reference 05

Yang et al. Hepatology 2020; 71 (4) :1154-1169

Other Product Names

IFI16 Antibody: Gamma-interferon-inducible protein 16, Ifi-16, Interferon-inducible myeloid differentiation transcriptional activator, IFNGIP1

Tested Applications

ELISA, WB, IF, IHC

Protein ID

118572657

Physical Properties

Liquid

Available Sizes

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