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TMEM41B (NT) Antibody

Product Specifications

Background

TMEM41B Antibody: TMEM41B is required for autophagosome formation and participates in early stages of autophagosome biogenesis at the ER membrane probably via mobilization of neutral lipids from lipid droplets. TMRM41B is a critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus. It is required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles.

NCBI Gene ID

440026

Swiss Prot

Q5BJD5

Accession Number

Q5BJD5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

9567

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease, COVID-19

Purification

TMEM41B Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1203 – A549 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Horse (100%) ; Chimpanzee (100%) .

Buffer

TMEM41B Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TMEM41B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=9567

Fragment

IgG

Symbol

TMEM41B

Positive Control 2

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

Transmembrane protein 41B

NCBI Organism

Homo sapiens

Background Reference 01

Moretti et al. EMBO Rep. 2018; 19 (9) :e45889.

Background Reference 02

Shoemaker et al. PLoS Biol. 2019; 17 (4) :e2007044.

Background Reference 03

Schneider et al. Cell 2021; 184 (1) :120-132.

Background Reference 04

Hoffmann et al. Cell 2021; 184 (1) :133-148.e20.

Other Product Names

TMEM41B Antibody: Transmembrane protein 41B, Protein stasimon, TMEM41B, KIAA0033.

Tested Applications

ELISA, IF, WB

Protein ID

74741383

Physical Properties

Liquid

Available Sizes

Curated Selection

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