POLRMT (CT) Antibody

Product Specifications

Background

POLRMT Antibody: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. POLRMT mutations impair mitochondrial transcription causing neurological disease. Knock-down of MRPL12 by RNA interference results in instability of POLRMT.

NCBI Gene ID

5442

Swiss Prot

O0411

Accession Number

O0411.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

9561

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

POLRMT Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1203 - A549 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Cow (82%) ; Chimpanzee (100%) ; monkey (82%) ; Cat (90%)

Buffer

POLRMT Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

POLRMT antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human POLRMT has 1 isoform (1230aa, 138.6kD) . Mouse POLRMT has one isoform (1207aa, 136.7kD) . Rat POLRMT has one isoform (1203aa, 135.8kD) . 9561 can detect POLRMT in human, mouse and rat.

Symbol

POLRMT

Positive Control 2

Cat. No. 1224 - Daudi Cell Lysate

NCBI Official Name

RNA polymerase mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Inatomi et al. Biochim Biophys Acta Mol Cell Res. 2022; 1869 (1) ; 119167

Background Reference 02

Olahova et al. Nat Commun. 2021; 12 (1) :1135

Background Reference 03

Nouws et al. J Biol Chem 2016; 291 (2) :989-997

Other Product Names

DNA-directed RNA polymerase, mitochondrial, MtRPOL, POLRMT Isoforms

Tested Applications

ELISA, WB, IF

Protein ID

50403691

Physical Properties

Liquid

Available Sizes

Curated Selection

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