ZC3H12A (CT) Antibody

Product Specifications

Background

ZC3H12A Antibody: ZC3H12A is an MCP1 (CCL2; MIM 158105) -induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis. ZC3H12A inhibits the Wnt/beta-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs. ZC3H12A ribonuclease can bind and cleave AURKA mRNA in MYCN-amplified neuroblastoma cells. ZC3H12A is a novel link between diabetogenic conditions and impaired insulin secretory capacity. ZC3H12A overexpression in human neuroblastoma cell lines causes cell-cycle arrest by G1/S checkpoint block.

NCBI Gene ID

80149

Swiss Prot

Q5D1E8

Accession Number

Q5D1E7.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

9547

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

ZC3H12A Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1701-01 - Human Lung Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chimpanzee (100%) ; Monkey (100%) ; Pig (79%) ; Chicken (83%)

Buffer

ZC3H12A Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ZC3H12A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human ZC3H12A has one isoform (599aa, 65.7kD) . Mouse has one isoform (596aa, 65.6kD) . Rat has one isoform (596aa, 65.9kD) . 9547 can detect ZC3H12A in human, mouse, and rat.

Symbol

ZC3H12A

Positive Control 2

Cat. No. 11-701 - Human Testis Tissue Slide

NCBI Official Name

Zinc finger CCCH-type containing 12A

NCBI Organism

Homo sapiens

Background Reference 01

Gorka et al. Oncogene. 2021; 40 (50) :6720-6735

Background Reference 02

Nowak et al. RNA Biol. 2021; 18 (1) :144-156

Background Reference 03

Tyka et al. Biochim Biophys Acta Mol Basis Dis. 2021; 1867 (10) :166199

Background Reference 04

Boratyn et al. J Cell Biochem. 2020; 121 (5-6) ;3406-3425

Other Product Names

ZC3H12A Antibody: Endoribonuclease ZC3H12A, Monocyte chemotactic protein-induced protein 1, MCP-induced protein 1, MCPIP-1, Zinc finger CCCH domain-containing protein 12A