PGAM5 (CT) Antibody

Product Specifications

Background

PGAM5 Antibody: PGAM5 is a central mediator for programmed necrosis induced by TNF and may be a regulator of mitochondrial dynamics. It displays phosphatase activity for serine/threonine residues, dephosphorylates and activates MAP3K5 kinase. It has apparently no phosphoglycerate mutase activity and is a substrate for a KEAP1-dependent ubiquitin ligase complex. It is also contributes to the repression of NFE2L2-dependent gene expression

NCBI Gene ID

192111

Swiss Prot

Q96HS1

Accession Number

Q96HS1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

9517

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

PGAM5 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1203 – A549 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: gorilla (100%) ; Chimpanzee (100%) ; monkey (100%) .

Buffer

PGAM5 Antibody is supplied in PBS containing 0.02% sodium azide

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PGAM5 antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human PGAM5 has 2 isoforms, including isoform 1 (289aa, 32kD), and isoform 2 (255aa, 28kD) . Mouse PGAM5 has 2 isoforms, including isoform 1 (288aa, 32kD) and isoform 2 (287aa, 31.9kD) . Rat PGAM5 has one isoform (288aa, 32kD) . 9517 can detect PGAM5 in human, mouse and rat

Symbol

PGAM5

Positive Control 2

Cat. No. 1282 – 3T3/NIH Cell Lysate

Positive Control 3

Cat. No. 1403 – Mouse Brain Lysate

NCBI Official Name

PGAM family member 5, mitochondrial serine/threonine protein phosphatase

NCBI Organism

Homo sapiens

Background Reference 01

Lo S. et al. Exp. Cell Res. 2018; 314 (8) : 1789-1803

Background Reference 02

Takeda et al. PNAS 2009; 106 (30) : 12301-12305

Background Reference 03

Want et al. Cell 2012; 148 (1-2) ; 228-243

Other Product Names

Serine/threonine-protein phosphatase PGAM5 mitochondrial, Bcl-XL-binding protein v68, Phosphoglycerate mutase family member 5

Tested Applications

ELISA, WB, IF

Protein ID

150417955

Physical Properties

Liquid

Available Sizes

Curated Selection

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