IRGB10 (NT) Antibody

Product Specifications

Background

IRGB10 Antibody: IRGB10 is an inferno-inducible protein that is essential for the activation of DNA-sensing AIM2 inflammasome, and contributes to the activation of LPS-sensing caspase-11 and NLRP3 inflammasome. IRGB10 is part of a conserved signaling hub at the interface between cell-autonomous immunity and innate immune sensing pathways. IRGB10 targets cytoplasmic bacteria and compromises bacterial structural integrity. IRGB10 and LIGP2 act together to confer differential susceptibility against Chlamydia infection in mice.

NCBI Gene ID

631323

Swiss Prot

AGY29631

Accession Number

AGY29631

Host

Rabbit

Reactivity

Mouse

Immunogen

9513

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Inflammasomes

Purification

IRGB10 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1405 – Mouse Kidney Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat (100%), Hamster (85%)

Buffer

IRGB10 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IRGB10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Mouse IRGB10 has 1 isoform (417aa, 47.2kD) .

Symbol

IRGB10

Positive Control 2

Cat. No. 1419 – Mouse Skin Lysate

Positive Control 3

Cat. No. 1411 – Mouse Colon Lysate

NCBI Official Name

Predicted gene 12250

NCBI Organism

Mus musculus

Background Reference 01

Man et al. Cell 2016; 167 (2) :382-396.e17

Background Reference 02

Bernstein-Hanley I et al. Proc Natl Acad Sci USA. 2006;103 (38) :14092-14097

Background Reference 03

Miyairi I et al. J Immunol 2007; 179 (3) :1814-1824

Background Reference 04

Coers J et al. J Immunol 2008; 180 (9) :6237-6245

Other Product Names

IRGB10 Antibody: Immunity-related GTPase family member b10, Interferon-gamma-inducible p47 GTPase, Gm12250, OTTMUSG00000005723

Tested Applications

ELISA, WB, IF

Protein ID

551032829

Physical Properties

Liquid

Available Sizes

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