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SARS-CoV-2 (COVID-19) NSP14 (ExoN) Antibody

Product Specifications

Background

Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP14 (ExoN) is an enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity (3,4,5) . It acts as a proofreading exoribonuclease for RNA replication, thereby lowering The sensitivity of the virus to RNA mutagens (6,7,8) .

NCBI Gene ID

43740578

Swiss Prot

P0DTC1

Accession Number

YP_009725309.1

Host

Rabbit

Reactivity

Virus

Immunogen

9187

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease, COVID-19

Purification

SARS-CoV-2 (COVID-19) NSP14 (ExoN) Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Homology

Predicted reactivity based on immunogen sequence: SARS-CoV NSP14 (ExoN) protein: (79%) .

Buffer

SARS-CoV-2 (COVID-19) NSP14 (ExoN) Antibody is supplied in PBS containing 0.02% sodium azide.

Shipping Conditions

Blue Ice

Storage Conditions

SARS-CoV-2 (COVID-19) NSP14 (ExoN) antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=9187

Fragment

IgG

Applications Notes

Antibody validated: SARS-CoV-2 (COVID-19) NSP14 (ExoN) antibody can detect 2 ng of free peptide at 1 μ g/mL in ELISA.

Symbol

ExoN

NCBI Official Name

ORF1a polyprotein; ORF1ab polyprotein

NCBI Organism

Severe acute respiratory syndrome coronavirus 2

Background Reference 01

Gorbalenya. bioRxiv: 2020.

Background Reference 02

Hui et al. Int J Infect Dis. 2020;91:264-266.

Background Reference 03

Minskaia et. al. Proc. Natl. Acad. Sci. U.S.A 2006; 103:5108-5113

Background Reference 04

Bouvet et. al. PLoS Pathog. 2010; 6:E1000863-E1000863

Background Reference 05

Bouvet et. al. Proc. Natl. Acad. Sci. U.S.A. 2012;109:9372-9377

Background Reference 06

Denison et. al. RNA Biol. 2011;8:270-279

Background Reference 07

Smith et. al. PLoS Pathog. 2013;9:e1003565-e1003565

Background Reference 08

Agostini et. al. MBio 2018; 9:0-0

Other Product Names

Proofreading exoribonuclease, Guanine-N7 methyltransferase, Non-structural protein 14, NSP14.

Tested Applications

ELISA

Protein ID

1802476817

Physical Properties

Liquid

Available Sizes

Curated Selection

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