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SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) Antibody

Product Specifications

Background

Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. 3C- like proteinase (NSP5) cleaves the C-terminus of replicase polyprotein at 11 sites (3,4,5) . It recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. It also able to bind an ADP-ribose-1''-phosphate (ADRP) (5) .

NCBI Gene ID

43740578

Swiss Prot

P0DTC1

Accession Number

YP_009742612.1

Host

Rabbit

Reactivity

Virus

Immunogen

9151

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease, COVID-19

Purification

SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Homology

Predicted reactivity based on immunogen sequence: SARS-CoV 3CL-PRO (NSP5) protein: (87%)

Buffer

SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) Antibody is supplied in PBS containing 0.02% sodium azide.

Shipping Conditions

Blue Ice

Storage Conditions

SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

3CL-PRO

NCBI Official Name

ORF1a polyprotein; ORF1ab polyprotein

NCBI Organism

Severe acute respiratory syndrome coronavirus 2

Background Reference 01

Gorbalenya. bioRxiv: 2020.

Background Reference 02

Hui et al. Int J Infect Dis. 2020;91:264-266.

Background Reference 03

Zhang et al. Science. 2020; 0:0-0 (2020)

Background Reference 04

Jin et al. Nature, 0:0-0 (2020)

Background Reference 05

Dai et al. Science 0:0-0 (2020)

Other Product Names

3C-like proteinase, 3CLp, nsp5, Non-structure protein 5, Main protease, Mpro

Tested Applications

ELISA, WB

Protein ID

1826688922

Physical Properties

Liquid

Available Sizes

Frequently Asked Questions

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