SIGLEC15 Antibody

Product Specifications

Background

SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig) -like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.

NCBI Gene ID

284266

Swiss Prot

Q6ZMC9

Accession Number

NP_998767

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

9017

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

SIGLEC15 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

SIGLEC15 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SIGLEC15 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human SIGLEC15 has 2 isoforms, including isoform 1 (328aa, 36kD) and isoform 2 (174aa, 18kD) . Mouse SIGLEC15 has one isoform (342aa, 37kD) and Rat SIGLEC15 also has one isoform (341aa, 37kD) . 9017 can detect human and possibly mouse and rat isoforms.

Symbol

SIGLEC15

Positive Control 2

Cat. No. 1211 - HepG2 Cell Lysate

Positive Control 3

Cat. No. 1220 - SK-N-SH Cell Lysate

Positive Control 4

Cat. No. 1304 - Human Liver Lysate

Positive Control 5

Cat. No. 1404 - Mouse Liver Lysate

Positive Control 6

Cat. No. 1463 - Rat brain Lysate

NCBI Official Name

Sialic acid binding Ig-like lectin 15

NCBI Organism

Homo sapiens

Background Reference 01

Crocker and Redelinghuys. Biochem. Soc. Trans. 2008; 36:1467-71.

Background Reference 02

Angata et al. Glycobiology 2007; 17:838-46.

Background Reference 03

Hiruma et al. Biochem. Biophys. Res. Commun. 2011; 409:424-9.

Other Product Names

SIGLEC15 Antibody: CD33L3, HsT1361, SIGLEC-15, CD33L3, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3, Siglec-15

Tested Applications

ELISA, WB

Protein ID

47106069

Physical Properties

Liquid

Available Sizes

Curated Selection

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