SOX10 Antibody

Product Specifications

Background

SOX10 Antibody: SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of the cell fate (1) . The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins (2) . This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development (2) . Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschprung disease (3) . SLC30A8 expression in beta-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4) .

NCBI Gene ID

6663

Swiss Prot

P56693

Accession Number

NP_008872

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

SOX10 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human SOX10.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Stem Cell

Purification

SOX10 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1461 - Rat Heart Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Pig: (100%), Chicken: (89%), Goat: (100%)

Buffer

SOX10 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SOX10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

SOX10 Antibody is predicted to not cross-react with other SOX familiy members.

Symbol

SOX10

NCBI Official Name

SRY-box 10

NCBI Organism

Homo sapiens

Background Reference 01

Pusch C, Hustert E, Pfeifer D, et al. The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum. Genet. 1998; 103:115-23.

Background Reference 02

Rehberg S, Lischka P, Glaser G, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol. Cell Biol. 2002; 22:5826-34.