GAS6 Antibody

Product Specifications

Background

The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla) -containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2) . GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3) . This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4) . Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2) .

NCBI Gene ID

2621

Swiss Prot

Q14393

Accession Number

NP_000811

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Homeostasis

Purification

GAS6 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1401 - Mouse Heart Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rabbit: (95%)

Buffer

GAS6 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GAS6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

GAS6 antibody is human, mouse and rat reactive. At least four isoforms of GAS6 are known to exist; this antibody will only detect the longest isoform.

Symbol

GAS6

NCBI Official Name

Growth arrest-specific 6

NCBI Organism

Homo sapiens

Background Reference 01

Schneider C, King RM, and Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell 1988; 54:787-93.

Background Reference 02

Laurance S, Lemarie CA, and Blostein MD. Growth arrest-specific gene 6 (gas6) and vascular hemostasis. Adv. Nutr. 2012; 3:196-203.

Background Reference 03

Stitt TN, Conn G, Gore M, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 1995; 80:661-70.