SLC36A2 Antibody

Product Specifications

Background

SLC36A2 is a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline (1,2) . Both SLC36A2 and its paralog SLC36A1 are expressed in neurons, but SLC36A2 localizes to the endoplasmic reticulum and recycling endosome, while SLC36A1 is expressed in the lysosome (2) . SLC36A2 is thought to contribute to neuronal transport and sequestration of amino acids such as glycine, alanine, and proline (2) . Mutations in this gene are associated with iminoglycinuria and hyperglycinuria (3) .

NCBI Gene ID

153201

Swiss Prot

Q495M3

Accession Number

NP_861441

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis, Neuroscience

Purification

SLC36A2 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1319 - Human Stomach Tissue Lysate

Concentration

1 mg/mL

Buffer

SLC36A2 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SLC36A2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

SLC36A2 antibody is human specific. SLC36A2 is predicted to not cross-react with other members of the SLC36 protein family.

Symbol

SLC36A2

NCBI Official Name

Solute carrier family 36 (proton/amino acid symporter), member 2

NCBI Organism

Homo sapiens

Background Reference 01

Boll M, Foltz M, Rubio-Aliaga I, et al. Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. J. Biol. Chem. 2002; 277:22966-73.

Background Reference 02

Rubio-Aliaga I, Boll M, Vogt Weisenhorn DM, et al. The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1. J. Biol. Chem. 2004; 279:2754-60.

Background Reference 03

Broer S, Bailey CG, Kowalczuk S, et al. Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. J. Clin. Invest. 2008; 118:3881-92.

Other Product Names

Solute carrier family 36 (proton/amino acid symporter) member 2, proton-coupled amino acid transporter 2, PAT2, TRAMD1

Tested Applications

ELISA, WB

Protein ID

222418631

Physical Properties

Liquid

Available Sizes

Curated Selection

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