RNF121 Antibody

Product Specifications

Background

RNF121 is an evolutionarily conserved E3 ligase ring finger protein that is expressed in the endoplasmic reticulum (1) . It acts downstream of the unfolded protein response regulator protein kinase-like endoplasmic reticulum kinase (PERK) . Overexpression of RNF121 during the early stages of gonad development led to aberrations in germline development and gonad migration, suggesting that it plays a role in endoplasmic reticulum-associated degradation machinery (1) .

NCBI Gene ID

552978

Swiss Prot

Q9H920

Accession Number

NP_060790

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

RNF121 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1219 - MCF7 Cell Lysate

Concentration

1 mg/mL

Buffer

RNF121 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RNF121 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

RNF121 antibody is human, mouse and rat reactive. Multiple isoforms of RNF121 are known to exist.

Symbol

RNF121

Positive Control 2

Cat. No. 17-012 - MCF7 Cell Slide

NCBI Official Name

Ring finger protein 121

NCBI Organism

Homo sapiens

Background Reference 01

Darom A, Bening-Abu-Shach U, and Broday L. RNF-121 is an endoplasmic reticulum-membrane E3 ubiquitin ligase involved in the regulation of B-integrin. Mol. Biol. Cell 2010; 21:1788-98.