Trophinin Antibody
Product Specifications
Background
Trophinin, also known as TRO or MAGED3, is an apical cell adhesion molecule that is implicated in the initial attachment during the process of embryo implantation and functions by mediating cell adhesion between trophoblastic and endometrial epithelial cells (1,2) . Trophinin is a membrane protein expressed in chorionic villi trophoblasts and in maternal endometrial epithelial cells in an implantation-dependent manner and interacts with Bystin and Tastin, facilitating cell adhesion and embryo implantation (3,4) . The induction of Trophinin expression may be a useful method for improving implantation rates and can be a potential diagnostic factor and biomarker for human cancer (4,5) .
NCBI Gene ID
7216
Swiss Prot
Q12816
Accession Number
NP_001034794
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell, Cancer, Apoptosis
Purification
Trophinin antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1464 - Rat Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
Trophinin antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Trophinin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=8245
Fragment
IgG
Specificity
Trophinin antibody is human, mouse and rat reactive. Multiple isoforms of Trophinin are known to exist.
Symbol
TRO
NCBI Official Name
Trophinin
NCBI Organism
Homo sapiens
Background Reference 01
Fukuda MN, Sato T, Nakayama J, et al. Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. Genes Dev. 1995; 9:1199-210.
Background Reference 02
Ma L, Yin M, Wu X, et al. Expression of trophinin and bystin identifies distinct cell types in the germinal zones of adult rat brain. Eur. J. Neurosci. 2006; 23:2265-76.
Background Reference 03
Tamura N, Sugihara K, Akama TO, et al. Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelial cells through PKC-d. Cell Cycle 2011; 10:135-43.
Background Reference 04
Chen KY, Lee YC, Lai JM, et al. Identification of trophinin as an enhancer for cell invasion and a prognostic factor for early stage lung cancer. Eur. J. Cancer. 2007; 43:782-90.
Other Product Names
TRO, MAGE-d3, MAGED3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
89276766
Physical Properties
Liquid
Available Sizes
Curated Selection
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