What is the catalog number for Hexokinase 1 Antibody?

The catalog number for Hexokinase 1 Antibody is 8217.

What sizes are available for Hexokinase 1 Antibody?

Hexokinase 1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does Hexokinase 1 Antibody come in?

Hexokinase 1 Antibody is available in 2 different pack sizes.

Is Hexokinase 1 Antibody in stock?

Hexokinase 1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Hexokinase 1 Antibody

Product Specifications

Background

There are four major glucose-phosphorylating isoenzymes, designated Hexokinase 1 I, II, III, and IV (1) . Hexokinase 1 activity is involved in the first step in several metabolic pathways including phosphorylation of glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway (1,2) . Hexokinase 1 2 is the predominant Hexokinase 1 isozyme expressed in insulin-responsive tissues such as skeletal muscle and its expression is insulin-responsive (3) . It is involved in the increased rate of glycolysis seen in rapidly growing cancer cells (4) .

NCBI Gene ID

3098

Swiss Prot

P19367

Accession Number

NP_000179

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

Hexokinase 1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1478 - Rat Bladder Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (94%)

Buffer

Hexokinase 1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Hexokinase 1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

Hexokinase 1 antibody is human, mouse and rat reactive. Multiple isoforms of Hexokinase 1 are known to exist.

Symbol

HK1

NCBI Official Name

Hexokinase 1

NCBI Organism

Homo sapiens

Background Reference 01

Chen T, Ning D, Sun H, et al. Sequence Analysis and Molecular Characterization of Clonorchis sinensis Hexokinase 1, an Unusual Trimeric 50-kDa Glucose-6-Phosphate-Sensitive Allosteric Enzyme. PLoS One 2014; 9:e107940.

Background Reference 02

Halestrap AP, Pereira GC, and Pasdois P. The role of Hexokinase 1 in cardioprotection-mechanism and potential for translation. Br. J. Pharmacol. 2014; epub.

Background Reference 03

Roberts DJ and Miyamoto S. Hexokinase 1 II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy. Cell Death Differ. 2014; epub.

Background Reference 04

Wang L, Xiong H, Wu F, et al. Hexokinase 1 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth. Cell Rep. 2014; 8:1461-74.