KIR2DS2 Antibody
Product Specifications
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1) . The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3) . KIR proteins are thought to play an important role in regulation of the immune response (3) . KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4) .
NCBI Gene ID
100132285
Swiss Prot
P43631
Accession Number
NP_036444
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
KIR2DS2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
KIR2DS2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KIR2DS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Observed Molecular Weight
Potentially post-translationally modified
Fragment
IgG
Specificity
KIR2DS2 antibody is human specific. Multiple isoforms are known to exist.
Symbol
KIR2DS2
Positive Control 2
Cat. No. 17-010 - HEK293 Cell Slide
NCBI Official Name
Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2
NCBI Organism
Homo sapiens
Background Reference 01
Colonna M and Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995; 268:405-8.
Background Reference 02
Biassoni R, Cantoni C, Falco M, et al. The human leukocyte antigen (HLA) -C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med. 1996; 183:645-50.
Background Reference 03
Wagtmann N, Biassoni R, Cantoni C, et al. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 1995; 2:439-49.
Background Reference 04
Moesta AK and Parham P. Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3. Front. Immunol. 2012; 3:336.
Other Product Names
Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2, KIR2DL3, MHC class I NK cell receptor, Natural killer-associated transcript 5, NKAT5, p58 KIR, p58 natural killer cell receptor clone CL-49, p58 NK receptor
Tested Applications
ELISA, WB, IF, ICC
Protein ID
6912472
Physical Properties
Liquid
Available Sizes
Frequently Asked Questions
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