KIR2DS2 Antibody

Product Specifications

Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1) . The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3) . KIR proteins are thought to play an important role in regulation of the immune response (3) . KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4) .

NCBI Gene ID

100132285

Swiss Prot

P43631

Accession Number

NP_036444

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

KIR2DS2 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Buffer

KIR2DS2 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KIR2DS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Observed Molecular Weight

Potentially post-translationally modified

Fragment

IgG

Specificity

KIR2DS2 antibody is human specific. Multiple isoforms are known to exist.

Symbol

KIR2DS2

Positive Control 2

Cat. No. 17-010 - HEK293 Cell Slide

NCBI Official Name

Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2

NCBI Organism

Homo sapiens

Background Reference 01

Colonna M and Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995; 268:405-8.

Background Reference 02

Biassoni R, Cantoni C, Falco M, et al. The human leukocyte antigen (HLA) -C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med. 1996; 183:645-50.

Background Reference 03

Wagtmann N, Biassoni R, Cantoni C, et al. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 1995; 2:439-49.

Background Reference 04

Moesta AK and Parham P. Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3. Front. Immunol. 2012; 3:336.

Other Product Names

Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2, KIR2DL3, MHC class I NK cell receptor, Natural killer-associated transcript 5, NKAT5, p58 KIR, p58 natural killer cell receptor clone CL-49, p58 NK receptor