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SRSF3 Antibody

Product Specifications

Background

SRSF3, a member of the serine/arginine (SR) -rich family of pre-mRNA splicing factors which constitute part of the spliceosome, may be involved in RNA processing in relation with cellular proliferation and/or maturation (1,2) . Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins (3) . The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation (3,4) .

NCBI Gene ID

6428

Swiss Prot

P84103

Accession Number

NP_003008

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis, Cancer

Purification

SRSF3 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1204 - K562 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Buffer

SRSF3 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SRSF3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=8179

Fragment

IgG

Specificity

SRSF3 antibody is human, mouse and rat reactive.

Symbol

SRSF3

NCBI Official Name

Serine/arginine-rich splicing factor 3

NCBI Organism

Homo sapiens

Background Reference 01

Sen S, Jumaa H, and Webster NJ. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat. Commun. 2013; 4:1336.

Background Reference 02

Gonçalves V, Matos P, and Jordan P. The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. RNA 2008; 14:2538-49.

Background Reference 03

Tang Y, Horikawa I, Ajiro M, et al. Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence. Oncogene 2013; 32:2792-8.

Background Reference 04

Jia R, Li C, McCoy JP, et al. SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance. Int. J. Biol. Sci. 2010; 6:806-26.

Other Product Names

Serine/arginine-rich splicing factor 3, Pre-mRNA-splicing factor SRP20, SFRS3, Splicing factor arginine/serine-rich 3, SRP20

Tested Applications

ELISA, WB, ICC, IF

Protein ID

4506901

Physical Properties

Liquid

Available Sizes

Curated Selection

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