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AJAP1 Antibody

Product Specifications

Background

The Adherens Junction Associated Protein 1 (AJAP1) plays a key role in cell adhesion and cell migration (1) . It is a transmembrane protein found on the basolateral surface of epithelium and expressed by multiple types of epithelium (1,2) . AJAP1 interacts with E-Cadherin and appears to promote the internalization of E-Cadherin upon growth factor stimulation (3) . This facilitates the dissolution of adherens junctions with an increase in cell motility (3,4) .

NCBI Gene ID

55966

Swiss Prot

Q9UKB5

Accession Number

NP_061324

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis, Cancer

Purification

AJAP1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1464 - Rat Liver Tissue Lysate

Concentration

1 mg/mL

Buffer

AJAP1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

AJAP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=8163

Fragment

IgG

Specificity

AJAP1 antibody is human, mouse and rat reactive.

Symbol

AJAP1

Positive Control 2

Cat. No. 17-004 - K-562 Cell Slide

NCBI Official Name

Adherens junctions associated protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Zeng L, Fee BE, Rivas MV, et al. Adherens junctional associated protein-1: a novel 1p36 tumor suppressor candidate in gliomas (Review) . Int. J. Oncol. 2014; 45:13-7.

Background Reference 02

Han L, Zhang KL, Zhang JX, et al. AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization. CNS Neurosci. Ther. 2014; 20:429-37.

Background Reference 03

Gross JC, Schreiner A, Engels K, et al. E-cadherin surface levels in epithelial growth factor-stimulated cells depend on adherens junction protein shrew-1. Mol. Biol. Cell 2009; 20:3598-607.

Background Reference 04

Lin N, Di C, Bortoff K, et al. Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. Mol. Cancer Res. 2012; 10:208-17.

Other Product Names

Adherens junctions associated protein 1, Membrane protein shrew-1, MOT8, SHREW1

Tested Applications

ELISA, WB, ICC

Protein ID

9055278

Physical Properties

Liquid

Available Sizes

Curated Selection

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