TENM1 Antibody

Product Specifications

Background

The teneurin transmembrane protein 1 (TENM1) is a member of a family of four neuronal cell surface proteins homologous to the Drosophila pair-rule gene Ten-m (1,2) . TENM1 is expressed primarily in the developing central nervous system and may be proteolytically cleaved with the intracellular domain translocating to the nucleus (3) . TENM1 is a direct target of the homeobox transcription factor EMX2, a transcription factor thought to be important for area specification in the developing cortex (4) .

NCBI Gene ID

10178

Swiss Prot

Q9UKZ4

Accession Number

NP_001156750

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell, Neuroscience

Purification

TENM1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1303 - Human Brain Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (83%)

Buffer

TENM1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TENM1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TENM1 antibody is human, mouse and rat reactive. TENM1 antibody is predicted to not cross-react with other members of the TENM family.

Symbol

TENM1

NCBI Official Name

Teneurin transmembrane protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Minet AD, Rubin BP, Tucker RP, et al. Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain. J. Cell Sci. 1999; 112:2019-32.

Background Reference 02

Rubin BP, Tucker RP, Martin D, et al. Tenurins: a novel family of neuronal cell surface proteins in vertebrates, homologous to the Drosophila pair-rule gene Ten-m. Dev. Biol. 1999; 216:195-209.

Background Reference 03

Kenzelmann D, Chiquet-Ehrismann R, Leachman NT, et al. Teneurin-1 is expressed in interconnected regions of the developing brain and processed in vivo. BMC Dev. Biol. 2008; 8:30.

Background Reference 04

Beckmann J, Vitobello A, Ferralli J, et al. Human teneruin-1 is a direct target of the homeobox transcription factor EMX2 at a novel alternate promoter. BMC Dev. Biol. 2011; 11:35.