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HOPX Antibody

Product Specifications

Background

HOPX is a small homeodomain protein that lacks normally conserved residues required for DNA binding (1) . It is thought to act downstream of NKX2-5 and modulates serum response factor (SRF) -dependent cardiac-specific gene expression and cardiac development (1) . HOPX also acts a tumor suppressor gene in multiple tumors and cancer cell lines (2,3) . HOPX has been reported to regulate the proliferation/differentiation homeostasis in different cell types, including keratinocytes (4) .

NCBI Gene ID

84525

Swiss Prot

Q9BPY8

Accession Number

NP_001138932

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Stem Cell

Purification

HOPX antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1303 - Human Brain Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat: (88%), Mouse: (88%), Bovine: (88%), Pig: (81%), Chicken: (81%)

Buffer

HOPX antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

HOPX antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=8143

Fragment

IgG

Specificity

HOPX antibody is human specific. At least three isoforms of HOPX are known to exist; this antibody will detect all three isoforms.

Symbol

HOPX

Positive Control 2

Cat. No. 10-501 - Human Heart Tissue Slide

NCBI Official Name

HOP homeobox

NCBI Organism

Homo sapiens

Background Reference 01

Chen F, Kook H, Milewski R, et al. Hop is an unusual homeobox gene that modulates cardiac development. Cell 2002; 110:713-23.

Background Reference 02

Asanoma K, Matsuda T, Kondo H, et al. NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. Genomics 2003; 81:15-25.

Background Reference 03

Katoh H, Yamashita K, Waraya M, et al. Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer. Neoplasia 2012; 14:559-71.

Background Reference 04

Obarzanek-Fojt M, Favre B, Kypriotou M, et al. Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes. Eur. J. Cell Biol. 2011; 90:279-90.

Other Product Names

HOP homeobox, homeodomain-only protein, CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

224451025

Physical Properties

Liquid

Available Sizes

Curated Selection

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