DNAJA4 Antibody

Product Specifications

Background

The DNAJA4 protein is the mammalian homolog of the chaperone HSP40 (1) and acts as a co-chaperone with the heat shock protein HSP70 (2) . DNAJA4 is highly expressed in heart and testis, accounting for approximately 1% of total protein in mouse heart (2) . DNAJA4 is also regulated by the sterol regulatory element binding transcription factor 2 (SREBF2) and plays a role in the synthesis of cholesterol (3) .

NCBI Gene ID

55466

Swiss Prot

Q8WW22

Accession Number

NP_061072

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

DNAJA4 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1320 - Human Colon Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (87%)

Buffer

DNAJA4 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DNAJA4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

DNAJA4 antibody is human, mouse, and rat reactive. At least three isoforms of DNAJA4 are known to exist; this antibody will detect all three isoforms.

Symbol

DNAJA4

NCBI Official Name

DnaJ homolog subfamily A member 4

NCBI Organism

Homo sapiens

Background Reference 01

Ohtsuka K and Hata M. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Cell Stress Chaperones 2000; 5:98-112.

Background Reference 02

Abdul KM, Terada K, Gotoh T, et al. Characterization and functional analysis of a heart-enriched DnaJ / Hsp40 homolog dj4/DjA4. Cell Stress Chaperones 2002; 7:156-66.

Background Reference 03

Robichon C, Varret M, Le Liepvre X, et al. DnajA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway. Biochim. Biophys. Acta 2006; 1761:1107-13.