SLC29A3 Antibody

Product Specifications

Background

SLC29A3 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1,2) . SLC29A3 is a transmembrane glycoprotein that localizes to the lysosomal membrane and is a broad selectivity, low affinity nucleoside transporter (3) . Mutations in the SLC29A3 gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism (4) . A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus (5) .

NCBI Gene ID

55315

Swiss Prot

Q9BZD2

Accession Number

NP_060814

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Homeostasis

Purification

SLC29A3 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1410 - Mouse Bladder Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

Buffer

SLC29A3 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SLC29A3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

SLC29A3 antibody is human, mouse and rat reactive. At least two isoforms of SLC29A3 are known to exist; this antibody will detect both isoforms. SLC29A3 antibody is predicted to not cross-react with other SLC29 proteins.

Symbol

SLC29A3

NCBI Official Name

Solute carrier family 29 (equilibrative nucleoside transporter), member 3

NCBI Organism

Homo sapiens

Background Reference 01

Hyde RJ, Cass CE, Young JD, et al. The ENT family of eukaryotic nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. Mol. Membr. Biol. 2001; 18:53-63.

Background Reference 02

Young JD, Yao SY, Baldwin JM, et al. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol. Aspects. Med. 34:529-47.

Background Reference 03

Baldwin SA, Yao SY, Hyde RJ, et al. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J. Biol. Chem. 2005; 280:15880-7.