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DNAJC13 Antibody

Product Specifications

Background

DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans (1) . It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles (2) . DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor (3) .

NCBI Gene ID

23317

Swiss Prot

O75165

Accession Number

NP_056083

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

DNAJC13 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1411 - Mouse Colon Tissue Lysate

Concentration

1 mg/mL

Buffer

DNAJC13 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DNAJC13 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=8109

Fragment

IgG

Specificity

DNAJC13 antibody is human and mouse reactive. At least two siforms of DNAJC13 are known to exist; this antibody will detect both isoforms. DNAJC13 antibody is predicted to not cross-react with other DNAJC family members.

Symbol

DNAJC13

Positive Control 2

Cat. No. 10-501 - Human Heart Tissue Slide

Positive Control 3

Cat. No. 1212 - 3T3 Cell Lysate

NCBI Official Name

DnaJ (Hsp40) homolog, subfamily C, member 13

NCBI Organism

Homo sapiens

Background Reference 01

Girard M, Poupon V, Blondeau F, et al. The DnaJ-domain protein RME-8 functions in endosomal trafficking. J. Biol. Chem. 2005; 280:40135-43.

Background Reference 02

Fujibayashi A, Taguchi T, Misaki R, et al. Human RME-8 is involved in membrane trafficking through early endosomes. Cell Struct. Funct. 2008; 33:35-50.

Background Reference 03

Girard M and McPherson PS. RME-8 regulates trafficking of the epidermal growth factor receptor. FEBS Lett. 2008; 582:961-6.

Other Product Names

DNAJ homolog subfamily C member 13, receptor-mediated endocytosis 8, RME8

Tested Applications

ELISA, WB, IHC-P

Protein ID

112421122

Physical Properties

Liquid

Available Sizes

Curated Selection

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