What is the catalog number for CTHRC1 Antibody?

The catalog number for CTHRC1 Antibody is 8101.

What sizes are available for CTHRC1 Antibody?

CTHRC1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does CTHRC1 Antibody come in?

CTHRC1 Antibody is available in 2 different pack sizes.

Is CTHRC1 Antibody in stock?

CTHRC1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

CTHRC1 Antibody

Product Specifications

Background

The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration (1) . CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells (2) . CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer (3) . Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma (4) .

NCBI Gene ID

115908

Swiss Prot

Q96CG8

Accession Number

NP_612464

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

CTHRC1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1468 - Rat Small Intestine Tissue Lysate

Concentration

1 mg/mL

Buffer

CTHRC1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CTHRC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

CTHRC1 antibody is human, mouse and rat reactive. At least two isoforms of CTHRC1 are known to exist; this antibody will detect only the larger isoform.

Symbol

CTHRC1

Positive Control 2

Cat. No. 11-801 - Human Small Intestine Tissue Slide

NCBI Official Name

Collagen triple helix repeat-containing protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Pyagay P, Heroult M, Wang Q, et al. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ. Res. 2005; 96:261-8.

Background Reference 02

Park EH, Kim S, Jo JY, et al. Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. Carcinogenesis 2013; 34:694-702.

Background Reference 03

Gu L, Liu L, Zhong L, et al. Cthrc1 overexpresion is an independent prognostic marker in gastric cancer. Hum. Pathol. 2014; 45:1031-8.

Background Reference 04

Orloff M, Peterson C, He X, et al. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. JAMA 2011; 306:410-9.