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MALT1 Antibody

Product Specifications

Background

MALT1 was initially identified as a novel gene that was recurrently rearranged in t (11;18) (q21; q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1) . MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2,3) . MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4) .

NCBI Gene ID

10892

Swiss Prot

Q9UDY8

Accession Number

NP_006776

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology

Purification

MALT1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1287 - EL4 Cell Lysate

Concentration

1 mg/mL

Buffer

MALT1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

MALT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=8097

Fragment

IgG

Specificity

MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist; this antibody will detect both isoforms.

Symbol

MALT1

Positive Control 2

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

Mucosa associated lymphoid tissue lymphoma translocation gene 1

NCBI Organism

Homo sapiens

Background Reference 01

Dielamm J, Baens M, Wlodarska I, et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t (11;18) (q21; q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999; 93:3601-9.

Background Reference 02

Lin X and Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin. Immunol. 2004; 16:429-35.

Background Reference 03

Rosebeck S, Rehman AO, Lucas PC, et al. From MALT lymphoma to the CBM signalsome: three decades of discovery. Cell Cycle 2011; 10:2485-96.

Background Reference 04

Staal J, Bekaert T, and Beyaert R. Regulation of NF-kB signaling by caspases and MALT1 paracaspase. Cell Res. 21:40-54.

Other Product Names

Mucosa associated lymphoid tissue lymphoma translocation 1, IMD12, MLT, MLT1

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

5803078

Physical Properties

Liquid

Available Sizes

Curated Selection

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