PRRX1 Antibody

Product Specifications

Background

The paired related homeobox protein 1 (PRRX1) is a paired-type DNA-binding homeodomain that plays an important role as a key switch for neural cell lineage determination and is essential for development (1,2) . PRRX1 is expressed in a number of undifferentiated mesenchymal cells in mouse embryos and adults (3) . Mice with a disrupted PRRX1 gene show perinatal death with craniofacial and limb malformations (4) . Low PRRX1 expression levels were significantly associated with metastasis and poor prognosis of breast and colorectal cancer (5) .

NCBI Gene ID

5396

Swiss Prot

P54821

Accession Number

NP_073207

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Stem Cell

Purification

PRRX1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (100%)

Buffer

PRRX1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PRRX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

PRRX1 antibody is human, mouse and rat reactive. At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.

Symbol

PRRX1

NCBI Official Name

Paired related homeobox 1

NCBI Organism

Homo sapiens

Background Reference 01

Nohno T, Koyama E, Myokai F, et al. Chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb. Dev. Biol. 1993; 158:254–64.

Background Reference 02

Shimozaki K, Clemenson GD Jr, and Gage FH. Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J. Neurosci. 2013; 33:4066-75.

Background Reference 03

Cserjesi P, Lilly B, Bryson L, et al. MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer. Development 1992; 115:1087–101.

Background Reference 04

Lu MF, Cheng HT, Kern MJ, et al. prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development 1999; 126:495–504.