FOXG1 Antibody

Product Specifications

Background

FOXG1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain and plays an important role in the development of the brain and telencephalon (1) . It is essential for the proliferation of progenitor cells in the cerebral cortex and influences regional patterning in the mammalian telencephalon (2,3) . Expression is restricted to the neurons of the developing telencephalon (3) . The loss of FOXG1 results in an accelerated rate of neuronal differentiation and the shortening of the neurogenetic period in the embryonic cerebral cortex (2,4) .

NCBI Gene ID

2290

Swiss Prot

P55316

Accession Number

NP_005240

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Stem Cell

Purification

FOXG1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1463 - Rat Brain Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (100%)

Buffer

FOXG1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FOXG1 antibody can be stored at 4˚ C, stable for up to one year.

Fragment

IgG

Specificity

FOXG1 antibody is human, mouse and rat reactive.

Symbol

FOXG1

NCBI Official Name

Forkhead box G1

NCBI Organism

Homo sapiens

Background Reference 01

Murphy DB, Wiese S, Burfeind P, et al. Human brain factor 1, a new member of the fork head gene family. Genomics 1994; 21:551-7.

Background Reference 02

Kumamoto T, Toma K, Gunadi, et al. Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression. Cell Rep. 2013; 3:931-45.

Background Reference 03

Miyoshi G and Fishell G. Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate. Neuron 2012;74:1045-58.

Background Reference 04

Mencarelli MA, Spanhol-Rosseto A, Artuso R, et al. Novel FOXG1 mutations associated with the congenital variant of Rett syndrome. J. Med. Genet. 2010; 47:49-53.

Other Product Names

Forkhead box G1, Brain factor 1, Brain factor 2, BF1, BF2, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, Forkhead box protein G1, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN