MYH3 Antibody

Product Specifications

Background

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells (1) . MYH3 (myosin, heavy chain, skeletal muscle, embryonic) plays a significant role in skeletal muscle development (2) and is also essential for the proper morphology and function of the developing heart (3) . Mutations in this gene have been associated with Freeman-Sheldon syndrome and Sheldon-Hall syndrome (4) .

NCBI Gene ID

4621

Swiss Prot

P11055

Accession Number

NP_002461

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

MYH3 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. XBL-10413 - Fetal Human Skeletal Muscle Lysate

Concentration

1 mg/mL

Buffer

MYH3 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

MYH3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

MYH3 antibody is human, mouse and rat reactive. MYH3 antibody is predicted to not cross-react with other members of the myosin heavy chain family.

Symbol

MYH3

NCBI Official Name

Myosin, heavy chain 3, skeletal muscle, embryonic

NCBI Organism

Homo sapiens

Background Reference 01

Yu H, Waddell JN, Kuang S, et al. Park7 expression influences myotube size and myosin expression in muscle. PLoS One 2014; 9:e92030.

Background Reference 02

Lagrutta AA, McCarthy JG, Scherczinger CA, et al. Identification and developmental expression of a novel embryonic myosin heavy-chain gene in chicken. DNA 1989; 8:39-50.

Background Reference 03

Rutland CS, Polo-Parada L, Ehler E, et al. Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart. Development 2011; 138:3955-66.

Background Reference 04

Toydemir RM, Rutherford A, Whitby FG, et al. Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Nat. Genet. 2006; 38:561-5.