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SLC1A7 Antibody

Product Specifications

Background

The solute carrier family 1 member 7 (SLC1A7) protein was initially identified as a glutamate transporter coupled to a chloride conductance that is expressed primarily in the retina (1) . More recent evidence indicates that is it widely expressed in peripheral tissues, also (2) . Experiments have shown that SLC1A7 functions as a low-affinity/low-capacity glutamate transport, with an anion channel optimized for anion conductance in the negative voltage range (3) . In the retina, SLC1A7 co-localizes with the serum and glucocorticoid dependent kinase SGK1, and its cell surface expression and activity is regulated SGK1 and its isoform SGK3 (4) .

NCBI Gene ID

6512

Swiss Prot

O00341

Accession Number

NP_001274524

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

SLC1A7 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1285 - C2C12 Cell Lysate

Concentration

1 mg/mL

Buffer

SLC1A7 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SLC1A7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=8083

Fragment

IgG

Specificity

SLC1A7 antibody is human and mouse reactive. Multiple isoforms of SLC1A7 are known to exist.

Symbol

SLC1A7

NCBI Official Name

Solute carrier family 1 (glutamate transporter), member 7

NCBI Organism

Homo sapiens

Background Reference 01

Arriza JL, Eliasof S, Kavanaugh MP, et al. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA 1997; 94:4155-60.

Background Reference 02

Lee A, Anderson AR, Stevens M, et al. Excitatory amino acid transporter 5 is widely expressed in peripheral tissues. Eur. J. Histochem. 2013; 57:e11.

Background Reference 03

Schneider N, Cordeiro S, Machtens JP, et al. Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. J. Biol. Chem. 2014; 289:1815-24.

Background Reference 04

Boehmer C, Rajamanickam J, Schniepp R, et al. Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3. Biochem. Biophys. Res. Commun. 2005; 329:738-42.

Other Product Names

Solute carrier family 1 (glutamate transporter) member 7, AAAT, excitatory amino acid transporter 5, EAAT5

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

567316146

Physical Properties

Liquid

Available Sizes

Curated Selection

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