TAU Antibody

Product Specifications

Background

The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3) . Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4) .

NCBI Gene ID

4137

Swiss Prot

P10636

Accession Number

NP_058519

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

TAU antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1220 - SK-N-SH Cell Lysate

Concentration

1 mg/mL

Buffer

TAU antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TAU antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TAU antibody is human, mouse and rat reactive. Multiple isoforms of TAU are known to exist; this antibody will only detect the two longest isoforms.

Symbol

TAU

Positive Control 2

Cat. No. 1463 - Rat Brain Tissue Lysate

NCBI Official Name

Microtubule-associated protein tau

NCBI Organism

Homo sapiens

Background Reference 01

Dotti CG, Banker GA, and Binder LI. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience 1987; 23:121-30.

Background Reference 02

Hanger DP, Brion JP, Gallo JM, et al. Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated. Biochem. J. 1991; 275:99–104.

Background Reference 03

Rocher AB, Crimins JL, Amatrudo JM, et al. Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp. Neurol. 2010; 223:385–93.

Background Reference 04

Galimberti D and Scarpini E. Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration. IInt. J. Clin. Exp. Med. 2010; 3:129-43.