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GJB2 Antibody

Product Specifications

Background

The Gap junction beta-2 protein (GJB2), also known as Connexin 26, is member of the gap junction protein family which form structures that were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells (1) . Mutations in the GJB2 gene are thought to be responsible for as much as 35-45% of congenital sensorineural hearing loss in some populations (2) . Other mutations in this gene have also been linked to a wide array of skin diseases (3) .

NCBI Gene ID

2706

Swiss Prot

P29033

Accession Number

NP_003995

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

GJB2 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1320 - Human Colon Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (94%), Sheep: (88%), Bovine: (88%), Chicken: (82%)

Buffer

GJB2 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GJB2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=8031

Fragment

IgG

Specificity

GJB2 antibody is human specific.

Symbol

GJB2

NCBI Official Name

Gap junction protein, beta 2, 26kDa

NCBI Organism

Homo sapiens

Background Reference 01

Zhou JZ and Jiang JX. Gap junctions and hemichannel-independent actions of connexins on cell and tissue functions – An update. FEBS Lett. 2014; 588:1186-92.

Background Reference 02

Petit C, Levilliers J, and Hardelin JP. Molecular genetics of hearing loss. Annu. Rev. Genet. 2001; 35:589-646.

Background Reference 03

Gerido DA and White TW. Connexin disorders of the ear, skin, and lens. Biochim. Biophys. Acta. 2004; 1662:159-70.

Other Product Names

Gap junction beta-2 protein, connexin 26, CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK

Tested Applications

ELISA, WB

Protein ID

42558283

Physical Properties

Liquid

Available Sizes

Curated Selection

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