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KCNK1 Antibody

Product Specifications

Background

The potassium channel, subfamily K, member 1 (KCNK1), is member of the superfamily of potassium channel proteins containing two pore-forming P domains (1,2) . KCNK1 is a ubiquitous human weakly inward rectifying K+ channel that is widely expressed in human tissues, and particularly abundant in brain and heart (1) . Both KCNK1 and the related protein KCNK2 contribute significantly to the passive conductance of hippocampal astrocytes (3) .

NCBI Gene ID

3775

Swiss Prot

O00180

Accession Number

NP_002236

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

KCNK1 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1212 - 3T3 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Bovine: (100%), Guinea pig: (100%)

Buffer

KCNK1 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KCNK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

KCNK1 antibody is human, mouse and rat reactive. KCNK1 antibody is predicted to not cross-react with other KCNK proteins.

Symbol

KCNK1

NCBI Official Name

Potassium channel, subfamily K, member 1

NCBI Organism

Homo sapiens

Background Reference 01

Lesage F, Guillemare E, Fink M, et al. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J. 1996; 15:1004-11.

Background Reference 02

Goldstein SA, Bockenhauer D, O'Kelly I, et al. Potassium leak channels and the KCNK family of two-P domain subunits. Nat. Rev. Neurosci. 2001; 2:175-84.

Background Reference 03

Zhou M, Xu G, Xie M, et al. TWIK-1 and TREK-2 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slides. J. Neurosci. 2009; 29:8551-64.

Other Product Names

Potassium channel subfamily K member 1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

4504847

Physical Properties

Liquid

Available Sizes

Frequently Asked Questions

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