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P2RX7 Antibody

Product Specifications

Background

The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1) . This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2) . Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2) . Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4) .

NCBI Gene ID

5027

Swiss Prot

Q99572

Accession Number

NP_002553

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Immunology

Purification

P2RX7 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1212 - 3T3 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat: (81%)

Buffer

P2RX7 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

P2RX7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=8015

Fragment

IgG

Specificity

P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.

Symbol

P2RX7

Positive Control 2

Cat. No. 17-201 - 3T3/BALB Cell Slide

NCBI Official Name

Purinergic receptor P2X, ligand-gated ion channel, 7

NCBI Organism

Homo sapiens

Background Reference 01

Surprenant A, Rassendren F, Kawashima E, et al. The cytosolic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7) . Science 1996; 272:735-8.

Background Reference 02

North RA. Molecular physiology of P2X receptors. Physiol. Rev. 2002; 82:1013-67.

Background Reference 03

Labasi JM, Petrushova N, Donovan C, et al. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 168:6436-45.

Background Reference 04

Basso AM, Bratcher NA, Harris RR, et al. Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety; relevance for neuropsychiatric disorders. Behav. Brain Res. 2009; 198:83-90.

Other Product Names

P2X purinoceptor 7, P2X7, purinergic receptor P2X ligand-gated ion channel 7

Tested Applications

ELISA, WB, ICC, IF

Protein ID

300068987

Physical Properties

Liquid

Available Sizes

Curated Selection

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