NLGN2 Antibody

Product Specifications

Background

Neuroligin 2 (NLGN2) is a member of a family of neuronal cell surface proteins that localize to the post-synaptic membrane (1,2) . Neuroligins are thought to act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses (2) . NLGN2 has been shown to control perisomatic inhibitory synapse maturation together with gephyrin and collybistin, thereby regulating GABA receptor clustering on neurons (3,4) . NLGN2 also exhibits differential functions at different types of inhibitory synapses on the same postsynaptic neuron (5) .

NCBI Gene ID

57555

Swiss Prot

Q8NFZ4

Accession Number

NP_065846

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

NLGN2 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1463 - Rat Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

NLGN2 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

NLGN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

NLGN2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. NLGN2 antibody is predicted to not cross-react with other members of the NLGN protein family.

Symbol

NLGN2

NCBI Official Name

Neuroligin 2

NCBI Organism

Homo sapiens

Background Reference 01

Ichtchenko K, Nguyen T, and Sudhof TC. Structures, alternative splicing, and neurexin binding of multiple neuroligins. J. Biol. Chem. 1996; 271:2676-82.

Background Reference 02

Bang ML and Owczarek S. A matter of balance: role of neurexin and neuroligin at the synapse. Neurochem. Res. 2013; 38:1174-89.

Background Reference 03

Poulopoulos A, Aramuni G, Meyer G, et al. Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitiory synapses through gephyrin and collybistin. Neuron 2009; 63:628-42.