PIK3R4 Antibody
Product Specifications
Background
PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4, also known as VPS15) is a 150kD adaptor protein that enhances the lipid kinase activity of PIK3 complexes and may be involved in regulating membrane trafficking late in the endocytic pathway and autophagy (1,2) . PIK3R4 is ubiquitously expressed and contains 7 WD repeats, 3 HEAT repeats and 1 protein kinase domain (1) . PIK3R4 is crucial for VPS34 function and is necessary for autophagosome formation in multicellular animals and reveal an important role of VPS15 in cellular protection against ubiquitin-positive protein aggregates (3-5) .
NCBI Gene ID
30849
Swiss Prot
Q99570
Accession Number
NP_055417
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
PIK3R4 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1315 - Human Tonsil Tissue Lysate
Concentration
1 mg/mL
Buffer
PIK3R4 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PIK3R4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=7949
Fragment
IgG
Specificity
PIK3R4 antibody is human, mouse and rat reactive.
Symbol
PIK3R4
NCBI Official Name
Phosphoinositide 3-kinase regulatory subunit 4
NCBI Organism
Homo sapiens
Background Reference 01
Herman PK, Stack JH, and Emr SD. A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery. EMBO J. 1991; 10:4049-60.
Background Reference 02
Stasyk OV, van der Klei IJ, Bellu AR, et al. A Pichia pastoris VPS15 homologue is required in selective peroxisome autophagy. Curr. Genet. 1999; 36:262-9.
Background Reference 03
Kihara A, Noda T, Ishihara N, et al. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 2001; 152:519-30.
Background Reference 04
Stack JH, DeWald DB, Takegawa K, et al. Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J. Cell Biol. 1995; 129:321-34.
Other Product Names
Phosphoinositide-3-kinase regulatory subunit 4, p150, Phosphoinositide 3-kinase adaptor protein, PI3-kinase p150 subunit, PI3-kinase regulatory subunit 4, VPS15
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
23943912
Physical Properties
Liquid
Available Sizes
Curated Selection
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