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Rubicon Antibody

Product Specifications

Background

Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation (1) . Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex (2) . Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines (2) .

NCBI Gene ID

9711

Swiss Prot

Q92622

Accession Number

XP_005269431

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Autophagy

Purification

Rubicon antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Buffer

Rubicon antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Rubicon antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7943

Fragment

IgG

Specificity

Rubicon antibody is human, mouse and rat reactive. Multiple isoforms of Rubicon are known to exist.

Symbol

KIAA0226

Positive Control 2

Cat. No. 10-401 - Human Kidney Tissue Slide

NCBI Official Name

KIAA0226

NCBI Organism

Homo sapiens

Background Reference 01

Matsunaga K, Saitoh T, Tabata K, et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 2009; 11:385-96.

Background Reference 02

Yang CS, Lee JS, Rodgers M, et al. Autophagy protein Rubicon mediates phagocytic NAPDH oxidase activation in response to microbial infection of TLR stimulation. Cell Host and Microbe 2012; 11:264-76.

Other Product Names

Run domain Beclin-1 interacting and cysteine-rich containing protein, KIAA0226

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

530375960

Physical Properties

Liquid

Available Sizes

Curated Selection

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