SHBG Antibody

Product Specifications

Background

SHBG is a steroid binding protein that was first described as a plasma protein secreted by the liver and is thought to participate in the regulation of steroid responses. SHBG transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers (1) . Low plasma SHBG levels are associated with obesity, abdominal adiposity, metabolic syndrome, and predict the development of type 2 diabetes (2,3) . Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus (4) .

NCBI Gene ID

6462

Swiss Prot

P04278

Accession Number

NP_001031

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity

Purification

SHBG antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1304 - Human Liver Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rabbit: (75%)

Buffer

SHBG antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SHBG antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

SHBG antibody is human, mouse, and rat reactive. At least three isoforms of SHBG are known to exist; this antibody will detect all three isoforms.

Symbol

SHBG

NCBI Official Name

Sex hormone-binding globulin

NCBI Organism

Homo sapiens

Background Reference 01

Siiteri PK, Murai JT, Hammond GL, et al. The serum transport of steroid hormones. Recent Prog. Horm. Res. 1982; 38:457-510.

Background Reference 02

Li C, Ford ES, Li B, et al. Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care 2010; 33:1618-24.

Background Reference 03

Ding EL, Song Y, Manson JE, et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N. Engl. J. Med. 2009; 361:1152-63.

Background Reference 04

Hacihanefioglu B, Aybey B, Hakan Ozon Y, et al. Association of anthropometric, androgenic and insulin-related features with polymorphisms in exon 8 of SHBG gene in women with polycystic ovary syndrome. Gynecol. Endocrinol. 2013; 29:361-4.