LIN54 Antibody
Product Specifications
Background
LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes. This complex functions as a transcriptional repressor by binding to promoters of E2F target genes that regulate the G1/S transition (1) . LIN54 is required for cell cycle progression and can bind to the cdc2 promoter in a sequence-specific manner (2) .
NCBI Gene ID
132660
Swiss Prot
Q6MZP7
Accession Number
NP_919258
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
LIN54 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
LIN54 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LIN54 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
LIN54 antibody is human, mouse, and rat reactive. Multiple isoforms of LIN54 are known to exist.
Symbol
LIN54
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Lin-54 homolog (C. elegans)
NCBI Organism
Homo sapiens
Background Reference 01
Schmit F, Cremer S, and Gaubatz S. LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promotoer in a sequence-specific manner. FEBS J. 2009; 276:5703-16.
Background Reference 02
Matsuo T, Kuramoto H, Kumazaki T, et al. LIN54 harboring a mutation in CHC domain is localized to the cytoplasm and inhibits cell cycle progression. Cell Cycle 2012; 11:3227-36.
Other Product Names
LIN-54, JC8.6, CXCDC1, MIP120
Tested Applications
ELISA, WB, ICC, IF
Protein ID
169234719
Physical Properties
Liquid
Available Sizes
Frequently Asked Questions
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