LIN54 Antibody

Product Specifications

Background

LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes. This complex functions as a transcriptional repressor by binding to promoters of E2F target genes that regulate the G1/S transition (1) . LIN54 is required for cell cycle progression and can bind to the cdc2 promoter in a sequence-specific manner (2) .

NCBI Gene ID

132660

Swiss Prot

Q6MZP7

Accession Number

NP_919258

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

LIN54 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

LIN54 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

LIN54 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

LIN54 antibody is human, mouse, and rat reactive. Multiple isoforms of LIN54 are known to exist.

Symbol

LIN54

Positive Control 2

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

Lin-54 homolog (C. elegans)

NCBI Organism

Homo sapiens

Background Reference 01

Schmit F, Cremer S, and Gaubatz S. LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promotoer in a sequence-specific manner. FEBS J. 2009; 276:5703-16.

Background Reference 02

Matsuo T, Kuramoto H, Kumazaki T, et al. LIN54 harboring a mutation in CHC domain is localized to the cytoplasm and inhibits cell cycle progression. Cell Cycle 2012; 11:3227-36.