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BAMBI Antibody

Product Specifications

Background

BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development (1) . BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4 (2,3) . BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues (4) . BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines (5) .

NCBI Gene ID

25805

Swiss Prot

Q13145

Accession Number

NP_036474

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Stem Cell

Purification

BAMBI antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1402 - Mouse Lung Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Sheep: (88%)

Buffer

BAMBI antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

BAMBI antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7931

Fragment

IgG

Specificity

BAMBI antibody is human, mouse and rat reactive.

Symbol

BAMBI

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

BMP and activin membrane-bound inhibitor

NCBI Organism

Homo sapiens

Background Reference 01

Onichtchouk D, Chen YG, Dosch R, et al. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 1999; 401:480-5.

Background Reference 02

Yan X, Lin Z, Chen F, et al. Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol. Chem. 2009; 284:30097-104.

Background Reference 03

Grotewold L, Plum M, Dildrop R, et al. Bambi is coexpressed with Bmp-4 during mouse embryogenesis. Mech. Dev. 2001; 100:327-30.

Background Reference 04

Fritzmann J, Morkel M, Besser D, et al. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 2009; 137:165-75.

Other Product Names

BMP and activin membrane-bound inhibitor homolog

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

6912534

Physical Properties

Liquid

Available Sizes

Curated Selection

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