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NOX4 Antibody

Product Specifications

Background

The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1) . NOX4 is is expressed in multiple tissues and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS) (2,3) . Unlike other NOX proteins, NOX4 does not require cytosolic subunits and thus is constitutively active (4) . The function of NOX4 remains unclear as it plays both protective and deleterious roles in cellular metabolism.

NCBI Gene ID

50507

Swiss Prot

Q9NPH5

Accession Number

NP_058627

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

NOX4 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1205 - Jurkat Cell Lysate

Concentration

1 mg/mL

Buffer

NOX4 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

NOX4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7927

Fragment

IgG

Specificity

NOX4 antibody is human, mouse, and rat reactive. At least four isoforms of NOX4 are known to exist. NOX4 is predicted to not cross-react with other NOX proteins.

Symbol

NOX4

Positive Control 2

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

NADPH oxidase 4

NCBI Organism

Homo sapiens

Background Reference 01

Bedard K and Krause KH. The Nox family of ROS-generating NAPDH oxidases: physiology and pathophysiology. Physiol. Rev. 2007; 87:245-313.

Background Reference 02

Cheng G, Cao Z, Xu X, et al. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 2001; 269:131-40.

Background Reference 03

Montezano AC, Burger D, Ceravolo GS, et al. Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5. Clin. Sci. 2011; 120:131-41.

Background Reference 04

Martyn KD, Frederick LM, von Loehneysen K, et al. Functional analysis of Nox4 reveals unique characteristics compared to other NAPDH oxidases. Cell. Signal. 2006; 18:69-82.

Other Product Names

NAPDH oxidase 4, NOX-4, RENOX, KOX, KOX-1

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

8393843

Physical Properties

Liquid

Available Sizes

Curated Selection

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