NOX3 Antibody

Product Specifications

Background

The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1) . NOX3 is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith (2,3) . It has been suggested that NOX3 is activated by the Transient Receptor Potential Vanilloid 1 (TRPV1), and this activity causes increased levels of reactive oxygen species in the inner ear, which in turn leads to STAT1-mediated inflammation and hearing loss (4) .

NCBI Gene ID

50508

Swiss Prot

Q9HBY0

Accession Number

NP_056533

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

NOX3 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Buffer

NOX3 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

NOX3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=7925

Fragment

IgG

Specificity

NOX3 antibody is human and mouse reactive. NOX3 is predicted to not cross-react with other NOX proteins.

Symbol

NOX3

Positive Control 2

Cat. No. 10-401 - Human Kidney Tissue Slide

NCBI Official Name

NADPH oxidase 3

NCBI Organism

Homo sapiens

Background Reference 01

Bedard K and Krause KH. The Nox family of ROS-generating NAPDH oxidases: physiology and pathophysiology. Physiol. Rev. 2007; 87:245-313.

Background Reference 02

Cheng G, Cao Z, Xu X, et al. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 2001; 269:131-40.

Background Reference 03

Paffenholz R, Bergstrom RA, Pasutto F, et al. Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev. 2004; 18:486-91.

Background Reference 04

Mukherjea, Jajoo S, Sheehan K, et al. NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss. Antioxidants and Redox Signaling 2011; 14:999-1010.

Other Product Names

NAPDH oxidase 3, NOX-3, GP91-3, MOX2, MOX-2

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

11136626

Physical Properties

Liquid

Available Sizes

Curated Selection

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