SOX17 Antibody

Product Specifications

Background

SOX17 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2) . SOX17 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types, including visceral and definitive endoderm and hematopoietic cell types (3,4) . SOX17 is also essential for acquisition and maintenance of arterial identity (5) .

NCBI Gene ID

64321

Swiss Prot

Q9H6I2

Accession Number

NP_071899

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

SOX17 antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1211 - HepG2 Cell Lysate

Concentration

1 mg/mL

Buffer

SOX17 antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SOX17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

SOX17 antibody is human, mouse and rat reactive. SOX17 is predicted to not cross-react with other SOX proteins.

Symbol

SOX17

NCBI Official Name

RY (sex determining region Y) -box 17

NCBI Organism

Homo sapiens

Background Reference 01

Kanai Y, Kanai-Azuma M, Noce T, et al. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J. Cell Biol. 1996; 133:667-81.

Background Reference 02

Jiang T, Hou CC, She ZY, et al. The SOX gene family: function and regulation in testis determination and male fertility maintenance. Mol. Biol. Rep. 2013; 40:2187-94.

Background Reference 03

Francois M, Koopman P, and Beltrame M. SoxF genes: key players in the development of the cardiovascular system. Int. J. Biochem. Cell Biol. 2010; 42:445-8.

Background Reference 04

Kim I, Saunders TL, and Morrison SJ. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 2007; 130:470-83.