SNCA Antibody

Product Specifications

Background

Alpha-Synuclein (SNCA) is a hallmark of Alzheimer's disease (1,2) . It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2) . SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3) . Defects in SNCA are associated with familial Parkinson's disease (4,5) .

NCBI Gene ID

6622

Swiss Prot

P37840

Accession Number

NP_000336

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Apoptosis

Purification

SNCA antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1412 - Mouse Cerebellum Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)

Buffer

SNCA antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SNCA antibody can be stored at 4˚ C for up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.

Symbol

SNCA

NCBI Official Name

Synuclein, alpha (non A4 component of amyloid precursor)

NCBI Organism

Homo sapiens

Background Reference 01

Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993; 90:11282-6.

Background Reference 02

Pronin AN, Morris AJ, Surguchov A, et al. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 2000; 275:26515-22.

Background Reference 03

Oaks AW, Frankfurt M, Finkelstein DI, et al. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS One 2013; 8:e60378.

Background Reference 04

Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997; 276:2045-7.